منابع مشابه
High-Dose Antiangiogenic Therapy for Glioblastoma: Less May Be More?
John F. de Groot Author’s Affiliations: Brain Tumor Center and Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX Running Title: Dosing effects of antiangiogenic therapy in glioblastoma
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The use of low dose continuous schedules of chemotherapy (i.e. metronomic chemotherapy), delivered at lower doses by necessity compared to traditional dosing schemes, has become an increasingly popular addition to patient management in veterinary medical oncology. While the concept itself is not new, as low dose, maintenance chemotherapy protocols have been important components of treatment for...
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I n a pivotal phase 3 randomized controlled trial, Hussain et al. tested the hypothesis that, with respect to survival, intermittent androgen deprivation therapy (ADT) is non-inferior to continuous in men with newly diagnosed metastatic prostate cancer. While the trial findings were statistically inconclusive, the study suggests, but does not prove, that intermittent may do more harm than good,...
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Calorie restriction (CR) extends lifespan and has been shown to reduce age-related diseases including cancer, diabetes, and cardiovascular and neurodegenerative diseases in experimental models. Recent translational studies have tested the potential of CR or CR mimetics as adjuvant therapies to enhance the efficacy of chemotherapy, radiation therapy, and novel immunotherapies. Chronic CR is chal...
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ژورنال
عنوان ژورنال: Blood
سال: 2016
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2016-07-726505